Nanoparticles for targeting the infarcted heart

نویسندگان

  • Michael Bauer
  • Avi Schroeder
  • Jonathan H. Tsui
  • Daniel G. Anderson
  • Robert Langer
  • Ronglih Liao
  • Daniel S. Kohane
چکیده

We report a nanoparticulate system capable of targeting the heart after myocardial infarction (MI). Targeting is based on overexpression of angiotensin II type 1 receptor (AT1) in the infarcted heart. Liposomes 142 nm in diameter were conjugated with a ligand specific to AT1. The nanoparticles were able to specifically target cardiac cells in vitro, and in the infarcted heart after intravenous injection in vivo. This system may be useful for delivering therapeutic agents specifically to the infarcted heart.

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تاریخ انتشار 2011